Antibiotic Formulary

	First Line	Second Line	​If patient is suspected or confirmed MRSA colonisation
​​​Allergy status (Confirm allergy status prior to choosing antimicrobial regime)	​ No pe​nicillin allergy/mild penicillin allergy​	​ Penicillin allergy	​
Antimicrobial   Check for interactions	Ceftriaxone and Metronidazole	Teicoplanin and Ciprofloxacin and Metronidazole	Teicoplanin and Ceftriaxone and Metronidazole
Dose	Ceftriaxone 2g every 12 hours and Metronidazole 500mg every 8 hours	Teicoplanin loading dose = 12mg/kg every 12 hours for 2 days (see guidelines for maintenance dose) and Ciprofloxacin 500mg every 12 hours and Metronidazole 400mg every 8 hours	Teicoplanin loading dose = 12mg/kg every 12 hours for 2 days (see guidelines for maintenance dose) and Ceftriaxone 2g every 12 hours and Metronidazole 500mg every 8 hours
Route	IV	IV Teicoplanin PO ciprofloxacin/metronidazole	​IV
Duration	Discuss with Medical Microbiology/Infectious Diseases

	First Line	Second Line
Antimicrobial	Discuss with Medical Microbiology/Infectious Diseases​
Dose
Route
Duration

• Prior to choosing antibiotic treatment, review previous microbiological results from a swab and MRSA status.
• Consider discussing with Med Micro/ID if exposure to water-borne pathogens, cellulitis related to penetrating injury, severe or non-improving soft tissue infection in a returned traveller.

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